The metastatic castration-resistant prostate cancer treatment paradigm: more choices, more questions

The metastatic castration-resistant prostate cancer treatment paradigm: more choices, more questions

opinions on pragmatic use and combinations for future exploration. Although, the topics may be drug-focused, there is the inclusion of broad discussion on entire fields of therapy with historical and pre-clinical perspective. This includes a review of traditional chemotherapy, immunotherapy, hormonal agents, bone-specific therapy and other pathways currently under exploration with therapeutic a...

Metastatic Castration-resistant Prostate Cancer: Major Progress Leading to Even More Questions.

Treatment of metastatic castration-resistant prostate cancer is complex and we are facing more questions with major practical impact with the available effective drugs. Treatment optimization requires that all clinical partners work together. Survival is linked to the number of regimen used. The androgen pathway is key, while chemotherapy is the other major tool.

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer

transcriptional activity, depends on a series of metabolic enzymes that catalyze the oxidation and reduction of steroid precursors from the adrenal gland or from cholesterol. A recent study by Chang et al.6 provides evidence that a gain-of-function 3βHSD1 somatic mutation contributes to prostate cancer progression by conferring resistance to proteasome-mediated degradation. 3βHSD1, like its oth...

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

In recent years, several nonhormonal and hormonal agents, including enzalutamide, have been approved for the treatment of metastatic castration-resistant prostate cancer (CRPC) on the basis of improved overall survival in prospective clinical trials. The incorporation of these agents has revolutionized the treatment of CRPC but has also raised the question of what is the ideal sequence of admin...

Complete Radiologic Response in Metastatic Castration-Resistant Prostate Cancer Treated with Cabazitaxel