منابع مشابه
The metabolism of glutaric acid-3-C14 by the intact rat.
Glutaric acid has been shown to be an intermediate in the mammalian catabolism of lysine (1). Two routes have been proposed for the degradation of glutaric acid (2-5). One pathway yields acetate, and the other involves a direct conversion to the carbon chain of ac-ketoglutarate. In an effort to assess the relative importance of each pathway, we have studied the metabolism of glutaric acid-3-Cl4...
متن کاملMammalian metabolism of glutaric acid.
Rat liver mitochondria metabolize glutarate at a very slow rate as compared with glutaryl coenzyme A. The stimulatory effect of citric acid cycle intermediates, NAD, and coenzyme A on glutarate metabolism was interpreted as a manifestation of their involvement in the activation of glutarate by a thiol transferase with succinyl-Cob as the coenzyme A donor. Glutaryl-CoA dehydrogenase, which catal...
متن کاملThe metabolism of ascorbic acid-1-C14 and oxalic acid-C14 in the rat.
It is known that oxalic acid is a product of ascorbic acid metabolism in the guinea pig (1) and rat (2), and is formed in man from unidentified precursors (3). Oxalates are also of interest because of their occasional toxicity and unexplained deposition. Ascorbic, dehydroascorbic, and 2,3diketogulonic acids are known to give rise to oxalic and threonic acids in approximately quantitative yields...
متن کاملThe Metabolism of Glutaric
Glutaric acid has been shown to be metabolized in part to acetoacetate and acetate in the rat, most probably by way of butyrate or acetonedicarboxylate (1). In addition, it was pointed out that part of the glutaric acid might also be converted to a-ketoglutarate by a more or less direct pathway. Study of the metabolism of lysine-6-Cl4 (2) has since provided substantial evidence in favor of this...
متن کاملMetabolism of pyruvic acid-2-C14 and hydroxypyruvic acid-2-C14 in algae.
The metabolism of pyruvic acid in the light and dark by Scenedesmus has been examined with two aims: to study the relationship of its metabolism to that of the intermediates of C1402 fixation and to compare its metabolic fate with that of hydroxypyruvate. The metabolism of hydroxypyruvic acid was compared with that of C1402 fixation in order to ascertain whether it might be a photosynthetic int...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1954
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)71174-5