THE MECHANISM OF ANAPHYLACTIC SHOCK

The Mechanism of Anaphylactic Shock

1. The serum ferments are practically unaltered by a primary injection of foreign protein. 2. During the course of sensitization the injection of the antigen is followed by the mobilization of a non-specific protease which increases in rapidity and intensity as the maximum period of sensitization is reached. 3. Acute shock is accompanied by: (a) The instantaneous mobilization of a large amount ...

Anaphylactic Shock

Anaphylactic shock is an unexpected, sudden and sometimes deadly event that attacks the patient in 75% of the cases without pre-existent history of allergy. In general, drugs, hymenopteric poisons and nutrients (according to the recent concept) are responsible. Beside the classical IgE-mediated anaphylactic shock there exists another anaphylactic shock, identical in its clinical picture and tre...

Anaphylactic Shock by Azodyes

Experiments are described which show that anaphylactic shock can be induced in animals sensitized with azoproteins by injecting them with azodyes containing the same azo components as the sensitizing antigen. The anaphylactic reactions are specific and occur with quantities of the dyes as small as fractions of milligrams.

Anaphylactic shock to raspberry.

Anaphylactic shock induced by diclofenac.

Diclofenac is a non-steroidal anti-inflammatory agent used in degenerative joint disease, rheumatoid arthritis, and allied conditions.' Its commonest unwanted effects include gastrointestinal disorders, rashes, peripheral oedema, and abnormalities of serum transaminase activity. More rarely, melaena and haematemesis, myoclonic encephalopathy, and myoclonus of the lower limbs may occur.2 3 We re...