The matricellular functions of small leucine-rich proteoglycans (SLRPs)
نویسندگان
چکیده
منابع مشابه
Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP.
PURPOSE The small leucine rich proteoglycan (SLRP) family is made up of several members which are thought to guide matrix assembly and organization through protein:protein and/or protein:carbohydrate interactions. In order to better characterize the composition of the scleral extracellular matrix, gene and protein expression of several members of the SLRP family were evaluated in the human scle...
متن کاملModulation of small leucine-rich proteoglycans (SLRPs) expression in the mouse uterus by estradiol and progesterone
BACKGROUND We have previously demonstrated that four members of the family of small leucine-rich-proteoglycans (SLRPs) of the extracellular matrix (ECM), named decorin, biglycan, lumican and fibromodulin, are deeply remodeled in mouse uterine tissues along the estrous cycle and early pregnancy. It is known that the combined action of estrogen (E2) and progesterone (P4) orchestrates the estrous ...
متن کاملSmall leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study
BACKGROUND Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to ...
متن کاملUsurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans?
Proteolytic degradation of articular cartilage macromolecules, including the large aggregating cartilage proteoglycan (aggrecan) and small leucine-rich proteoglycans (SLRPs), is a prominent pathophysiological feature of arthritic diseases such as osteoarthritis (OA). Molecular profiling and monitoring of soluble/circulating proteoglycan catabolites that may be released from the cartilage matrix...
متن کاملSmall leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice.
Remodelling of the extracellular matrix (ECM) occurs during decidualization of the endometrium in mice. Previously we have documented the appearance of large-diameter collagen fibrils around mature decidual cells between day 5 and day 7 of pregnancy. Proteoglycans are important in the regulation of collagen fibrillogenesis, and the present study analysed four members (decorin, biglycan, lumican...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2009
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-009-0066-2