The many faces of marginal zone lymphoma

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Splenic marginal zone lymphoma: hydra with many heads?

In this issue of the Journal, Baseggio et al. 1 report on a series of 24 patients with CD5-positive, t(11;14)-negative splenic marginal zone lymphoma (SMZL) diagnosed by means of cytology and flow cytometry of peripheral blood. All the patients were splenectomized at diagnosis or during follow-up and, consequently, spleen specimens were available for histological examination in all cases. The b...

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Splenic marginal zone lymphoma.

Splenic marginal zone lymphoma (SMZL) is a specific low-grade small B-cell lymphoma that is incorporated in the World Health Organization classification. Characteristic features are splenomegaly, moderate lymphocytosis with villous morphology, intrasinusoidal pattern of involvement of various organs, especially bone marrow, and relative indolent course. Tumor progression with increase of blasti...

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Radiotherapy in marginal zone lymphoma

PURPOSE To evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL). MATERIALS AND METHODS Patients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n = 12), stomach (n = 8), head and neck other than the orbita (n = 8), breast (n = 1) and one case of mar...

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Marginal Zone B-cell lymphoma

Extra-nodal MZBCL of MALT type (7% of all NHL) is an indolent disease involving most often the stomach, where it usually follows chronic gastritis due to Helicobacter pylori (HP) infection. The disease may also localize in the lung, the thyroid, the salivary gland, the orbit. Splenic MZBCL (1% of all NHL on histologic samples) usually, though not invariably, presents splenomegaly associated cir...

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Primary marginal zone lymphoma of the thymus.

Primary low-grade B-cell lymphomas of the thymus are rare, with only 7 reported cases in the literature. We describe 3 cases of primary low-grade thymic lymphoma. All had histologic features of extranodal marginal zone lymphoma and were composed predominantly of small lymphocytes with variable components of monocytoid cells and plasma cells. Overt transformation to large cell lymphoma occurred ...

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ژورنال

عنوان ژورنال: Hematology

سال: 2012

ISSN: 1520-4391,1520-4383

DOI: 10.1182/asheducation.v2012.1.426.3798535