The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as virulence genes: response
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چکیده
منابع مشابه
Identification of regions of the chromosome of Neisseria meningitidis and Neisseria gonorrhoeae which are specific to the pathogenic Neisseria species.
Neisseria meningitidis and Neisseria gonorrhoeae give rise to dramatically different diseases. Their interactions with the host, however, do share common characteristics: they are both human pathogens which do not survive in the environment and which colonize and invade mucosa at their port of entry. It is therefore likely that they have common properties that might not be found in nonpathogeni...
متن کاملAnimal models for pathogenic Neisseria species.
The development and use of various animal models in the early 1970s helped renew interest in the immunobiology of Neisseria gonorrhoeae and N. meningitidis. This research also provoked controversy concerning which infection model provided the most useful information. Certainly, the human host or isolated organ cultures provided a relevant test system for neisserial infections; however, these mo...
متن کاملRecent Advances in the Pathogenic Neisseria Research
Introduction Neisseria meningitidis, a Gram-negative bacteria, is an important cause of bacterial meningitis and septicemia worldwide [1]. Meningococcal disease is a life-threatening illness that may progress to death even after medical intervention. Despite treatment with appropriate antibiotic therapy, the case fatality rate remains high, and survivors can have significant sequelae, including...
متن کاملThe pathogenic potential of commensal species of Neisseria.
Although Neisseria species other than N gonorrhoeae and N meningitidis normally comprise part of the commensal bacterial flora of the oropharynx, they may occasionally act as opportunistic pathogens. Infections in which these organisms have been implicated include cases of endocarditis, meningitis, septicaemia, otitis, bronchopneumonia and possibly genital tract disease. In this paper, the clin...
متن کاملAntimutator role of DNA glycosylase MutY in pathogenic Neisseria species.
Genome alterations due to horizontal gene transfer and stress constantly generate strain on the gene pool of Neisseria meningitidis, the causative agent of meningococcal (MC) disease. The DNA glycosylase MutY of the base excision repair pathway is involved in the protection against oxidative stress. MC MutY expressed in Escherichia coli exhibited base excision activity towards DNA substrates co...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2006
ISSN: 1471-2164
DOI: 10.1186/1471-2164-7-129