The lymphoid system and experimental neoplasias

The lymphoid system and experimental neoplasias.

In the last decade or so immunologists have left the test tubes in which their serological mysteries were enacted and turned to consider the cells which are involved in immune responses. The resultant cellular immunologists have made discoveries which ought to have lent precision to the quite old notion that the immune mechanism is part of the natural defence system which, in vertebrates, can o...

Lymphoid neoplasias. II. Clinical and therapeutic aspects.

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Direct effect of rituximab in B-cell-derived lymphoid neoplasias: mechanism, regulation, and perspectives.

The anti-CD20 monoclonal antibody rituximab is the backbone of treatment for the B-cell malignancies non-Hodgkin lymphoma and chronic lymphocytic leukemia. However, there is a wide variability in response to rituximab treatment, and some patients are refractory to current standard therapies. Rituximab kills B cells by multiple mechanisms of action, including complement-dependent cytotoxicity an...

Pathology of the Lymphoid System

Neoplasias of the colorectal crypts.

Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas. That neoplasias may also arise in the colorectal crypts is less well known. Between 1998 and 2002, colonoscopies, rectoscopies and colorectal surgical specimens from 8647 patients were received at this Department for histological diagnosis. The m...