The local lymph node assay and the assessment of relative potency: status of validation
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چکیده
منابع مشابه
The local lymph node assay and the assessment of relative potency: status of validation.
For the prediction of skin sensitization potential, the local lymph node assay (LLNA) is a fully validated alternative to guinea-pig tests. More recently, information from LLNA dose-response analyses has been used to assess the relative potency of skin sensitizing chemicals. These data are then deployed for risk assessment and risk management. In this commentary, the utility and validity of the...
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Use of the local lymph node assay for the estimation of relative contact allergenic potency.
The effective toxicological evaluation of skin sensitization demands that potential contact allergens are identified and that the likely risks of sensitization among exposed populations assessed. By definition, chemicals which possess the toxicological property of skin sensitization potentially are capable of causing allergic contact dermatitis (ACD) in humans. However, this hazard is not an al...
متن کاملMeasurement of allergenic potency using the local lymph node assay.
Chemicals that can act as contact allergens have been identified successfully using guinea-pig models. However, contact allergy is still common, probably because of, at least in part, failures of risk assessment. A new method, the local lymph node assay, replaces the guinea-pig as a tool for hazard identification and offers the real prospect of accurate prediction of allergen potency, the missi...
متن کاملLocal lymph node assay: validation assessment for regulatory purposes.
For the prediction of skin sensitization potential of substances, the murine local lymph node assay (LLNA) is an alternative to the widely used guinea pig tests. For more than 10 years, this method has undergone extensive development, evaluation, and validation. In this review, the validation status of the LLNA is considered, specifically with regard to its use for regulatory identification of ...
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ژورنال
عنوان ژورنال: Contact Dermatitis
سال: 2007
ISSN: 0105-1873,1600-0536
DOI: 10.1111/j.1600-0536.2007.01141.x