The Life History of Pyrroloquinoline Quinone (PQQ): A Versatile Molecule with Novel Impacts on Living Systems
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منابع مشابه
The Life History of Pyrroloquinoline Quinone (PQQ): A Versatile Molecule with Novel Impacts on Living Systems
Pyrroloquinoline quinone (4, 5-dihydro(4), 5-dioxo(1) H-pyrroloquinoline-2,7, 9 tricarboxylic acid) being a three ortho cyclic quinone substitutes the role of a redox-cofactor for various bacterial dehydrogenases such as methanol, ethanol and glucose dehydrogenases [1-6] also termed as methotaxin [7]. PQQ structure prediction shows that it has been originated from tyrosine and Glutamic-acid [8]...
متن کاملThe pyrroloquinoline quinone (PQQ)-containing quinoprotein dehydrogenases.
L. (1995) Biochemistry 34, 11080-1 1089 10 Friden, H. and Hederstedt, L. (1990) Mol. Microbiol. 4, 1045-1056 1 1 Nakamura, K., Yamaki, M., Sarada, M., Nakayama, S., Vibat, C. R. T., Gennis, R. B., Nakayashiki, T., Inokuchi, H., Kojima, S. and Kita, K. (1996) J. Biol. Chem. 271, 521-527 12 Hagerhall, C. and Hederstedt, L. (1996) FEBS Lett. 389, 25-31 13 Pennoyer, J. D., Ohnishi, T. and Trumpower...
متن کاملA subchronic oral toxicity study on pyrroloquinoline quinone (PQQ) disodium salt in rats.
A subchronic oral toxicity study on pyrroloquinoline quinone (PQQ) disodium salt was performed in rats. Sprague-Dawley rats were randomly divided into four groups (10 rats/sex/group) and administered with PQQ disodium salt at doses of 0 (control), 100, 200 and 400 mg/kg bw/day by gavage for 13 weeks. Daily clinical observations and weekly measurement of body weights and food consumption were co...
متن کاملIdentification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein
Pyrroloquinoline quinone (PQQ), a redox-active o-quinone, is an important nutrient involved in numerous physiological and biochemical processes in mammals. Despite such beneficial functions, the underlying molecular mechanisms remain to be established. In the present study, using PQQ-immobilized Sepharose beads as a probe, we examined the presence of protein(s) that are capable of binding PQQ i...
متن کاملRegulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)
Hitherto unknown effects of Pyrroloquinoline quinone (PQQ) in 6-n-propyl-2-thiouracil (PTU)induced oxidative stress and lipid peroxidation were investigated in adult mice. Animals received either PTU (0.05% in drinking water) alone for 5 weeks or PTU + three different concentrations of PQQ, after which alterations in tissue lipid peroxidation (LPO) and in enzymatic activities of superoxide dism...
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ژورنال
عنوان ژورنال: International Journal of Molecular Biology
سال: 2016
ISSN: 2573-2889
DOI: 10.15406/ijmboa.2016.01.00005