The Killing of African Trypanosomes by Ethidium Bromide
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چکیده
منابع مشابه
The Killing of African Trypanosomes by Ethidium Bromide
Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB has long been known to cause loss of the mitochondrial genome, named kinetoplast DNA (kDNA), a giant network of interlocked minicircles and maxicircles. However, the existence of viable parasites lacking kDNA (dyski...
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When starved, exponential phase cells of Saccharomyces cerevisiae are exposed to lo-25 UM ethidium bromide in buffer, the proportion of respiration deficient mutants in the population exhibits a rapid increase, followed by a pronounced decrease. This "self-rescue" by the mutagen can be dissociated from and studied independently of its mutagenic action and is shown to exhibit different requireme...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2010
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1001226