THE ISOLATION OF VITAMIN K2
نویسندگان
چکیده
منابع مشابه
Vitamin K2 Monograph
Introduction Vitamin K is a fat-soluble vitamin essential for the functioning of several proteins involved in blood clotting.1 Discovered in 1929 by Danish scientist Henrik Dam, the vitamin received the letter “K” because the initial discoveries were reported in a German journal in which the substance was designated as “Koagulationsvitamin.” Research during the last 30 years has resulted in gre...
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During the last 20 years, the main clinical effects of vitamin K2 on bone homeostasis have been investigated in both indirect and direct vitamin K treatment regimens. This chapter is mainly based on randomized clinical trials (RCT) lasting for more than 1 year. As for vitamin K1 (phylloquinone, indirect treatment) and vitamin K2 (menaquinone MK‐4 and MK‐7 direct treatment), respectively, the cl...
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Vitamin K is a cofactor required for post-translational gamma-carboxylation of vitamin K-dependent proteins, including coagulation and anti-coagulation factors; osteocalcin (OC), essential for bone metabolism; and matrix Gla proteins (MGP), an inhibitor of artery calcification. In addition to activation of OC, vitamin K2 induces collagen accumulation in the bone matrix. The principle effects of...
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Aerobic and anaerobic respiratory systems allow cells to transport the electrons to terminal electron acceptors. The quinone (ubiquinone or menaquinone) pool is central to the electron transport chain. In the majority of gram-positive bacteria, vitamin K2 (menaquinone) is the sole quinone in the electron transport chain, and thus, the bacterial enzymes catalyzing the synthesis of menaquinone ar...
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This article covers in vitro, in vivo, and human data on the positive effect of vitamin K2 on osteoporosis. Data is available on vitamin K2 for osteoporosis caused by a number of conditions, including postmenopausal osteoporosis, Parkinson's disease, biliary cirrhosis, stroke, and drug-induced osteoporosis. The activity of vitamin K2 involves both an increase in the bone-building process and a ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1939
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)73506-0