منابع مشابه
The IRF family of transcription factors
Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and-as a consequence-for adaptive i...
متن کاملThe IRF family transcription factors at the interface of innate and adaptive immune responses.
The interferon-regulatory factor (IRF) family, originally identified as transcriptional regulators of the type I interferon system, consists of nine members in mammals. A large number of studies have revealed the versatile and critical functions performed by this transcription factor family in immunity and other biological processes. Most notably, the advances in the study of signal transducing...
متن کاملThe Expression of BAFF Is Controlled by IRF Transcription Factors.
Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) are typically characterized by the presence of autoantibodies and an IFN-signature. The strength of the IFN-signature positively correlates with disease severity, suggesting that type I IFNs are active players in these diseases. BAFF is a cytokine critical for development and proper selection of B cells, and t...
متن کاملType I interferon system and IRF family of transcription factors in host defense regulation
Type I interferons (IFN-α /β) were originally identified as humoral factors, which are secreted in virally infected cells and confer an antiviral state in uninfected cells. Subsequently, their multifunctional roles have also been demonstrated, which include antitumor actions. More recently, the IFN system has been the focus of much attention in the context of the regulation of the innate and ad...
متن کاملDifferential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection.
Members of the IFN regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. Although related by homology at their N-terminal DNA-binding domain, they display individual functional properties. The distinct properties result from differences in regulated expression, response to activating signals, and interaction with DNA regulatory elem...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2012
ISSN: 2162-402X
DOI: 10.4161/onci.22475