The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo
نویسندگان
چکیده
منابع مشابه
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Defects in primary cilia result in human diseases known as ciliopathies. The retinitis pigmentosa GTPase regulator (RPGR), mutated in the most severe form of the eye disease, is located at the transition zone of the ciliary organelle. The RPGR-interacting partner PDEδ is involved in trafficking of farnesylated ciliary cargo, but the significance of this interaction is unknown. The crystal struc...
متن کاملThe interplay between RPGR, PDEdand Arl2/3 regulate the ciliary targeting of farnesylated cargo
Defects in primary cilia result in human diseases known as ciliopathies. The retinitis pigmentosa GTPase regulator (RPGR), mutated in the most severe form of the eye disease, is located at the transition zone of the ciliary organelle. The RPGR-interacting partner PDEd is involved in trafficking of farnesylated ciliary cargo, but the significance of this interaction is unknown. The crystal struc...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2013
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2013.37