The interaction of inositol hexaphosphate with methaemoglobin

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The interaction of inositol hexaphosphate with methaemoglobin.

1. Inositol hexaphosphate causes the shape of the oxidation-reduction equilibrium curve to become hyberbolic at acid pH values. 2. Inositol hexaphosphate also causes a decrease in the alkaline oxidation Bohr effect at these same pH values. 3. These results support the idea that inositol hexaphosphate causes methaemoglobin to take up the deoxyhaemoglobin quaternary structure at pH6.5.

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A significant anticancer activity of the naturally occurring carbohydrate inositol hexaphosphate (IP(6)) has been reported against numerous cancer models. Since tumors require angiogenesis for growth and metastasis, we hypothesize that IP(6) reduces tumor growth by inhibiting angiogenesis. Because angiogenesis depends on the interaction between endothelial and tumor cells, we investigated the e...

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Interaction of methemoglobin with inositol hexaphosphate. Presence of the T state in human adult methemoglobin in the low spin state.

The interaction of human methemoglobin with inositol hexaphosphate (IHP) was examined by proton NMR spectroscopy. Upon addition of IHP, new proton peaks which are distinguishable from those observed in the absence of IHP appeared irrespective of the spin state of the ferric heme iron. the IHP-induced NMR peaks of low spin azide methemoglobin were not observed when azide was titrated to stripped...

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Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1973

ISSN: 0264-6021

DOI: 10.1042/bj1330725