The inhibitory mechanism of presynaptic α2-adrenoceptors on sympathetic ganglia
نویسندگان
چکیده
منابع مشابه
Presence of prejunctional D2-dopaminoceptors and α2-adrenoceptors on the cholinergic nerve of the common bile duct of guinea pig
On most adrenergic and cholinergic nerve terminals, prejunctional α-adrenoceptors belonging to the α2-subtype have been identified. Activation of these receptors will decrease the release of norepinephrine. It has been reported that several isolated tissue preparations contain prejunctional dopamine receptors, the stimulation of which inhibits neurotransmission. It has remained uncertain whethe...
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Responses to bath-applications of 4-aminopyridine(4-AP) and gamma-aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion. 4-aminopyridine (0.1-1.0 mmol/l) usually induced spontaneous action potentials and excitatory postsynaptic potentials (EPSPs), which were blocked by hexamethonium. Membrane potential was unchanged; spike duration w...
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Presynaptic autoreceptors were discovered by six groups of researchers in 1971. The receptors of 1971 were autoreceptors regulating the release of noradrenaline, acetylcholine and GABA (Starke et al. 1989). The ®rst 10 years after 1971 yielded the basic evidence. Carlsson (1975) coined the term `autoreceptors', receptors `sensitive to the neuron's own transmitter substance'. It was recognized t...
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The effect of adenosine triphosphate (ATP) on the release of acetylcholine (ACh) from presynaptic nerve terminals was investigated in bullfrog sympathetic ganglia. ATP decreased the amplitude and quantal content of fast excitatory postsynaptic potentials (fast e.p.s.p.s) calculated from the variance of fast e.p.s.p. amplitude in a low Ca2+-high Mg2+ Ringer solution. The frequency of miniature e...
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قاعده مقتضی و مانع در متون فقهی کم و بیش مستند احکام قرار گرفته و مورد مناقشه فقهاء و اصولیین می باشد و مشهور معتقند مقتضی و مانع، قاعده نیست بلکه یکی از مسائل ذیل استصحاب است لذا نگارنده بر آن شد تا پیرامون این قاعده پژوهش جامعی انجام دهد. به عقیده ما مقتضی دارای حیثیت مستقلی است و هر گاه می گوییم مقتضی احراز شد یعنی با ماهیت مستقل خودش محرز گشته و قطعا اقتضاء خود را خواهد داشت مانند نکاح که ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1986
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)59480-x