The inhibition of oxidative phosphorylation
نویسندگان
چکیده
منابع مشابه
The inhibition of oxidative phosphorylation.
Loomis & Lipmann (1948) showed that low concentrations of 2:4-dinitrophenol (DNP) reversibly uncouple the phosphorylation associated with the oxidation of glutamate. This supported the hypothesis that agents such as DNP, which prevent the use of the energy provided by respiration and glycolysis, do so by inhibiting the formation of highenergy phosphate bonds (Lardy & Elvehjem, 1945; McElroy, 19...
متن کاملInhibition of Oxidative Phosphorylation in Escherichia Coli by Dihydrostreptomycin.
Bragg, P. D. (University of British Columbia, Vancouver, B.C., Canada), and W. J. Polglase. Inhibition of oxidative phosphorylation in Escherichia coli by dihydrostreptomycin. J. Bacteriol. 86:1236-1240. 1963.-Dihydrostreptomycin inhibited the oxidation of succinate in extracts of antibiotic-sensitive Escherichia coli. The inhibitable reaction required both the particulate and the supernatant f...
متن کاملPhosphate Dependence and Atractyloside Inhibition of Mitochondrial Oxidative Phosphorylation
ATP production and oxygen consumption by rat liver mitochondria were measured as a function of atractyloside and phosphate (Pi) concentration. The “on” kinetics of atractyloside inhibition of ATP production are very rapid, and the onset of inhibitory effect is complete within 1 s even at concentrations which produce partial inhibition. A ligand conservation plot relating atractyloside concentra...
متن کاملRegulation of Oxidative Phosphorylation
Introduction Thyroid hormones (TI Is) affect cellular metabolism via two different pathways. The first one is the socalled nuclear, long-term effect: there the TI I binds to a nuclear receptor and regulates the transcription o f multiple cellular proteins f 11. The other pathway, the short-term extranuclear pathway, is less w d l defined and could in principle be similar to other short-term sig...
متن کاملUncouplers of oxidative phosphorylation.
Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they show very potent activities. The most poten...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1951
ISSN: 0306-3283
DOI: 10.1042/bj0480033