منابع مشابه
Crumbs turns the corner
rumbs (Crb) helps flies distinguish apical from basal in their epithelia. Now two new studies show that it is required for cell expansion independently of its specification of apical polarity. During cell expansion, the apical domain of photoreceptors elongates perpendicular to the apical–basal axis so that the domain can extend from the top to the bottom of the fly eye. The process may be cons...
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What is it? The inflammasome is a multiprotein complex of more than 700 kDa that is responsible for the activation of caspases 1 and 5, leading to the processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18. Two types of inflammasome have been identified to date — the NALP1 inflammasome, composed of NALP1, the adaptor protein ASC, caspase 1 and caspase 5, and the NALP2/3 infl...
متن کاملEstrogen turns down "the AIRE".
Genetic alterations are known drivers of autoimmune disease; however, there is a much higher incidence of autoimmunity in women, implicating sex-specific factors in disease development. The autoimmune regulator (AIRE) gene contributes to the maintenance of central tolerance, and complete loss of AIRE function results in the development of autoimmune polyendocrinopathy syndrome type 1. In this i...
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The idea of a harmonious universe is one with which scientists and philosophers have sympathized for centuries. Of course, many such as Tolman[11], have revealed difficulties with original oscillatory models, typically citing divergent entropy or difficulty with singularities. By scientific judgement and recent developments[2, 10, 8], I am compelled to resort to such a model in the description ...
متن کاملLateral turns in the Lamprey. II. Activity of reticulospinal neurons during the generation of fictive turns.
We studied the neural correlates of turning movements during fictive locomotion in a lamprey in vitro brain-spinal cord preparation. Electrical stimulation of the skin on one side of the head was used to evoke fictive turns. Intracellular recordings were performed from reticulospinal cells in the middle (MRRN) and posterior (PRRN) rhombencephalic reticular nuclei, and from Mauthner cells, to ch...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/548534a