The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1
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چکیده
منابع مشابه
The importin β / importin 7 heterodimer is a functional nuclear import receptor for histone H 1
Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely mediated by nuclear transport receptors of the importin β family that use direct RanGTP-binding to regulate the interaction with their cargoes. We investigated nuclear import of the linker histone H1 and found that two receptors, importin β (Impβ) and importin 7 (Imp7, RanBP7), play a critical role in thi...
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After synthesis in the cytoplasm, H1 histones are imported into the nucleus through an energy-dependent process that can be mediated by an importin beta-importin 7 (Impbeta-Imp7) heterodimer. H1 histones contain two structurally different types of nuclear localization signals (NLS). The first type of NLS resides within the unstructured C-terminal domain and is rich in basic amino acids. In cont...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 0261-4189,1460-2075
DOI: 10.1093/emboj/18.9.2411