The Importance of STK11/LKB1 Assessment in Non-Small Cell Lung Carcinomas
نویسندگان
چکیده
منابع مشابه
Role of metallothionein expression in non-small cell lung carcinomas.
Metallothionein (MT) is a low molecular weight protein, which participates in differentiation and proliferation of normal and tumour cells. In some malignant tumours (mammary, renal, ovarian cancers), its increased expression is thought to represent an unfavourable prognostic factor. Non-small-cellular lung cancers (mainly squamocellular cancer and adenocarcinoma) are characterised by ill-defin...
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Non-small cell lung carcinoma (NSCLC) from histological and biological perspectives is a complex neoplasm. The sequential preneoplastic changes have been defined for centrally arising squamous cell carcinomas (SCCs) of the lung, and they are less documented for peripherally arising adenocarcinomas. The main morphologic forms of preneoplastic lesions recognized in the lung are squamous dysplasia...
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Background: Lung cancer is the most common cause of cancer death worldwide with an annual mortality rate of more than 1.3 million worldwide. We aimed to analyze the clinicopathological features of patients with non-small-cell lung cancer (NSCLC) in west of Iran. Methods: 64 patients with NSCLC who referred to our clinic were analyzed. Sex, age, histopathology, location of the tumor, treatment,...
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Lung cancer is classified into small-cell carcinoma (SCLC) and non-small-cell carcinoma (NSCLC). The profile of molecular and genetic alterations considerably differs between SCLC and NSCLC, as well as among the subtypes of NSCLC. Tp53 is inactivated in nearly 50% of NSCLC, while its mutations with functional inactivation are greatly prevalent in SCLC (70-100%). Rb gene alterations and protein ...
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AbstractObjective: To investigate the impact of respiratory motion on localization, and quantification lung lesions for the Gross Tumour Volume utilizing an in-house developed Auto3Dreg programme and dynamic NURBS-based cardiac-torso digitised phantom (NCAT). Methods: Respiratory motion may result in more than 30% underestimation of the SUV values of lung, liver and kidney tumour lesions. The m...
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ژورنال
عنوان ژورنال: Diagnostics
سال: 2021
ISSN: 2075-4418
DOI: 10.3390/diagnostics11020196