THE IMPACT OF DELAYED PROGESTERONE START ON PREMATURE LUTEINIZATION AND PREGNANCY OUTCOMES IN MEDICATED FROZEN EMBRYO TRANSFER CYCLES
نویسندگان
چکیده
To determine the prevalence of premature luteinization in patients undergoing medicated frozen embryo transfer (FET) cycles where delayed start micronized progesterone is needed after last transvaginal ultrasound (TVUS) done. Retrospective cohort study FET at Mount Sinai Fertility (MSF), Canada between February 2019 and March 2020. At MSF, a protocol involves starting estradiol (4 mg PO/PV BID) on menstrual cycle day 2 for 12 days when TVUS done to assess endometrial thickness. Micronized 200 PV TID begun lining reaches thickness ≥ 8 mm. Embryo thaw occurs 6th progesterone. No blood tests are routinely If final delay initiation required days, LH levels measured that planned begin ensure has not occurred. cyst seen TVUS, also drawn breakthrough follicular development and/or ovulation cancelled if detected (progesterone > 5 nmol/L). Natural, modified natural, non-standard protocols or donor egg were excluded. Primary outcome was with TVUS. Secondary outcomes clinical pregnancy intrauterine gestation rate starts compared those without. A total 881 performed, which 238 had serum levels. In 91 due initiation, 147 because US. Mean age cryopreservation 34.40 years (SD 3.68) 35.48 3.85) start. evidence (0/91). significant difference found either (47.67% vs. 48.15%, p=0.9347) (70.73% 82.05%, p=0.0876) Premature US using 4 BID our population. Delaying deemed be adequate did impact rates. Additional endocrine monitoring therefore missed this protocol.
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2021
ISSN: ['0015-0282', '1556-5653']
DOI: https://doi.org/10.1016/j.fertnstert.2021.07.642