The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats

Traditional medicine has been developed rapidly throughout the world to treat hyperlipidemia. However, use of a single compound in hyperlipidemia treatment usually have low efficacy. Therefore, combination ingredients is bound more synergistic impact therapy. This research aimed examine hypolipidemic potential mountain papaya (MPE) and bitter melon fruit ethanolic extract (BME) alloxan-induced rats. Forty rats divided into eight groups were used this study. Groups are normal control, negative positive as well MPE BME which doses three doses. Induction 150 mg/kg alloxan intraperitoneally performed generate model diabetes The was carried out for four weeks experiment. both extracts sufficiently exhibited activity (p < 0.05). levels lipid profiles total such cholesterol, triacylglycerides, low-density lipoprotein, high-density very lipoprotein decreased after administration also action equivalent simvastatin. combined papaya, extracts, improve biochemical (lipid profile) modifications alloxan-induced.