The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
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منابع مشابه
The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
Mutations in SLC26A4, which encodes pendrin, are responsible for hearing loss with an enlarged vestibular aqueduct and Pendred syndrome. The most prevalent mutation in East Asia is p.H723R (His723Arg), which leads to defects in protein folding and cell-surface expression. Here we show that H723R-pendrin can be rescued to the cell surface by an HSP70 co-chaperone DNAJC14-dependent unconventional...
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Catherine Rabouille, Vivek Malhotra and Walter Nickel* Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands Centre for Genomic Regulation, C/ Dr. Aiguader 88, 08003 Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluı́s Companys 23, 08010 Barcelona, Spain Heidelberg University Biochemistry Center,...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms11386