The Honeybee Venom Major Allergen Api m 10 (Icarapin) and Its Role in Diagnostics and Treatment of Hymenoptera Venom Allergy
نویسندگان
چکیده
منابع مشابه
Component resolved diagnostics for hymenoptera venom allergy
PURPOSE OF REVIEW Component-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. RECENT FINDINGS Component resolution in HVA has moved from single molecules to ...
متن کاملGenomic and transcriptional analysis of protein heterogeneity of the honeybee venom allergen Api m 6
Several components of honeybee venom are known to cause allergenic responses in humans and other vertebrates. One such component, the minor allergen Api m 6, has been known to show amino acid variation but the genetic mechanism for this variation is unknown. Here we show that Api m 6 is derived from a single locus, and that substantial protein-level variation has a simple genome-level cause, wi...
متن کاملTryptase and Hymenoptera Venom Allergy
Antecedentes: La gravedad de la reacción tras una picadura de himenópteros se ha relacionado con la presencia de niveles elevados de triptasa sérica. El propósito del estudio fue cuantifi car los niveles basales de triptasa en pacientes con alergia al veneno de himenópteros e investigar la posible correlación entre estos niveles y la gravedad de la reacción a la picadura. Métodos: Participaron ...
متن کاملAllergy to insect stings. II. Phospholipase A: the major allergen in honeybee venom.
In order to determine the proteins of major allergenic importance in honeybee venom (Apis mellifera) it was chromatographed on G-50 Sephadex. The four major protein peaks eluted were identified as hyaluronidase, phospholipase, melittin, and apamin. Testing these preparations on the leukocytes of 6 honeybee-sensitive patients, with the in vitro method of histamine release, revealed that all indi...
متن کاملDiagnostics in Hymenoptera venom allergy: current concepts and developments with special focus on molecular allergy diagnostics
BACKGROUND The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer ins...
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ژورنال
عنوان ژورنال: Current Allergy and Asthma Reports
سال: 2020
ISSN: 1529-7322,1534-6315
DOI: 10.1007/s11882-020-00943-3