The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome
نویسندگان
چکیده
منابع مشابه
Inhibition of microRNA-19b promotes ovarian granulosa cell proliferation by targeting IGF-1 in polycystic ovary syndrome
The purpose of the present study was to investigate the functional role of microRNA (miR)-19b in polycystic ovary syndrome (PCOS) and try to elucidate its underlying mechanisms. Expression of miR‑19b and insulin‑like growth factor 1 (IGF-1) was examined in ovarian cortexes [(from 18 women with PCOS and 10 who did not have PCOS (non‑PCOS)] and KGN cells. Cell proliferation assays (cell viability...
متن کاملComprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell
Polycystic ovary syndrome (PCOS) affects approximately 7% of the reproductive-age women. A growing body of evidence indicated that epigenetic mechanisms contributed to the development of PCOS. The role of DNA modification in human PCOS ovary granulosa cell is still unknown in PCOS progression. Global DNA methylation and hydroxymethylation were detected between PCOS' and controls' granulosa cell...
متن کاملPolycystic ovary syndrome. Polycystic ovary syndrome.
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متن کاملThe effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome
BACKGROUND The influence of estradiol (E2) on granulosa cell (GC) function has not been tested clinically in women with polycystic ovary syndrome (PCOS). The objective of this study is to determine if E2 influences GC responses to FSH in women with PCOS. METHODS This is a two phase, single cohort study conducted over a 2-year period at a single academic center. Nine women with PCOS according ...
متن کاملEffect of Vitamin D3 on Mitochondrial Biogenesis in Granulosa Cells Derived from Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by anovulation hyperandrogenism.Hyperandrogenism increases apoptosis, which will eventually disturb follicular growth in PCOS patients.Since mitochondria regulate apoptosis, they might be affected by high incidence of follicular atresia. This may causeinfertility. Since vitamin D3 has been shown to...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2018
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2018-00544