The HLA library for drug screening in preventing severe drug hypersensitivity
نویسندگان
چکیده
منابع مشابه
The HLA library for drug screening in preventing severe drug hypersensitivity
Background The clinical and economic impact of severe drug hypersensitivity is huge for both healthcare and pharmaceutical industry; however, no method for predicting culprit candidate t drugs under clinical development exists currently. As genetic variants in human-leukocyte antigens (HLA) have been linked to inter-individual differences in the risk of drug hypersensitivity, we ascertained whe...
متن کاملDrug Induced Hypersensitivity and the HLA Complex
Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs, and can be initiated by a wide range of structurally diverse chemical compounds. The pathophysiological mechanisms underlying hypersensitivit...
متن کاملHLA and pharmacogenetics of drug hypersensitivity.
Immunologically mediated drug reactions have been traditionally classified as unpredictable based on the fact that they cannot be predicted strictly on the pharmacological action of the drug. Such adverse drug reactions are associated with considerable morbidity and include severe cutaneous adverse reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis and the drug hypersensitivi...
متن کاملHLA and Delayed Drug-Induced Hypersensitivity.
Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). Based on the identification of these associations, it may now be possible to pr...
متن کاملDynamics of chemokines in severe drug hypersensitivity
Background Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) / drug-induced hypersensitivity syndrome (DIHS) are recognized as severe cutaneous adverse reactions (SCARs) usually induced by drugs. Due to the high risk of mortality, management of patients with SCARs requires rapid diagnosis. However, it is difficul...
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ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2014
ISSN: 2045-7022,2045-7022
DOI: 10.1186/2045-7022-4-s3-p51