منابع مشابه
The HLA crossroad in tumor immunology.
It is generally accepted that human and experimental tumor cells can lose major histocompatibility complex (MHC) class I molecules. These human leukocyte antigen (HLA) losses are detected when the primary tumor breaks the basal membrane, invades the surrounding tissues, and starts to metastasize. These altered HLA class I phenotypes probably constitute the major tumor escape mechanism facing an...
متن کاملTumor immunology.
Malignant tumors express antigens that may stimulate and serve as targets for antitumor immunity. Virally induced tumors usually contain integrated proviral genomes in theircellulargenomes and often express viral genome-encoded proteins that may stimulate specific host immune responses. Antigens unique to individual tumors that stimulate specific rejection of transplanted tumors have been demon...
متن کاملTumor immunology.
N. Franklin Adkinson, Jr. Chester A. Alper Philip W, Askenase Kenneth A. Ault Michael K. Bach Anthony Basten Michael A. Bean Celso Bianco P. E. Bigazzi R. Michael Blaese Phyllis B. Blair R. V. Blanden Kurt J. Bloch Harvey Cantor Charles B. Carpenter Bruce Chesebro Martin J. Cline Zanvil A. Cohn Daniel G, Colley Robert B, Colvin Robert B. Couch Natalie E. Cremer Susan E. Cullen Agustin P. Dalmas...
متن کاملTumor immunology: new perspectives.
This second meeting, organized by the Cancer Immunology Working Group of AACR, concentrated mainly on three areas of importance; these included (a) ways to increase the success rate of vaccination by improving the peptides themselves, improving tumor recognition by using costimulatory molecules or the use of antibodies; (b) how the tumor microenvironment influences T-cell activity and how it ca...
متن کاملHLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa.
The human leukocyte antigen-A (HLA-A), -B and -DRB1 polymorphism was examined in the Portuguese population, discriminating between North, Centre and South inhabitants. All data were obtained at high-resolution level, using sequence-based typing. The most frequent allele at each locus was A* 020101 (26%), B* 440301 and B* 510101 (12% each) and DRB1* 070101 (15%). The predominant three-locus hapl...
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ژورنال
عنوان ژورنال: Human Immunology
سال: 2000
ISSN: 0198-8859
DOI: 10.1016/s0198-8859(99)00156-1