The Hippi did it

The Hippi did it

and colleagues have identified a protein called Hippi as one possible mediator of Huntington disease (HD) neuronal cell death. HD begins with expansion of the polyglutamine repeats in the huntingtin protein (Htt). This frees up Hip1 protein, which normally binds to Htt. Free Hip1 can then bind to the Hippi protein identified by Nicholson, and the two proteins join in a complex with procaspase 8...

Perhaps the FOMC Did What It Said It Did: An Alternative Interpretation of the Great Inflation

Bank of Canada working papers are theoretical or empirical works-in-progress on subjects in economics and finance. The views expressed in this paper are those of the authors. No responsibility for them should be attributed to the Bank of Canada. ii Acknowledgements We received many valuable comments from participants of the 2006 Workshop on Macroeconomic Forecasting, Analysis and Policy with Da...

It shouldn't have happened, but it did.

Unwitnessed head trauma: the bamboo did it

Unwitnessed penetrating head injuries (PHIs) are often challenging. The inability to locate a foreign body should not exclude this diagnosis nor should it delay treatment. Attempts must be made to clarify the mechanism of injury, as this may allow for a better understanding of the patient's condition.

Penis captivus--did it occur?

The symptom of penis captivus during sexual intercourse has had a largely hearsay existence in medical history, and rumour has embellished the drama of its occurrence. It is not entirely mythical, however. It seems to have been a symptom of great rarity in former times and to have vanished perhaps completely in this century.