The genetics of self-reported trait impulsivity: Contribution of catecholaminergic gene variants in European ancestry individuals

Increased trait impulsivity is a core element in several mental disorders. Given the durable and consistent nature of impulsivity, studies have explored its relation to stable biological measures. Variation catecholaminergic neurotransmission by genetic variants could be one these substrates. Here, 905 participants European-ancestry completed Barratt Impulsiveness Scale–11 were genotyped three single nucleotide polymorphisms related neurotransmission: DRD2/ANKK Taq1A, C957T DRD2 Val158Met COMT gene. We found significant main effects on BIS-11 score. Also, interactions with gender both SNPs tendency slightly different genotype allele associations BIS-total score between male female participants. Whereas females, higher scores obtained heterozygous (Met/Val), data indicate trend towards Val-allele carriers. In case C957T, only tentative association T-allele carriers comparison CC established. No Taq1A. provide further evidence for gender-specific implication impulsivity.