THE FORMATION OF SEDOHEPTULOSE PHOSPHATE FROM PENTOSE PHOSPHATE
نویسندگان
چکیده
منابع مشابه
Enzymatic formation of pentose phosphate from 6-phosphogluconate.
In 1933 (1) Warburg and Christian reported the formation of 6-phosphogluconate from glucose-6-phosphate and later the further oxidation of phosphogluconate (2). Triphosphopyridine nucleotide (TPN), the coenzyme for both reactions, was isolated from horse red blood cells. Further investigation of the oxidation of 6-phosphogluconate revealed subsequent decarboxylation, without participation of ph...
متن کاملThe pentose phosphate pathway.
I received my basic training in enzymology as a graduate student in the laboratory of Professor T. R. Hogness at the University of Chicago from 1936 to 1939. Hogness had constructed a photoelectric spectrophotometer modeled after the one in Otto Warburg’s laboratory in Berlin-Dahlem. I was assigned a problem on succinic dehydrogenase from beef heart, using the Warburg manometric apparatus, and ...
متن کاملPentose phosphate pathway
5 Abbreviations 6PGD 6-phosphogluconate dehydrogenase ADP adenosine diphosphate ATP adenosine triphosphate CSF cerebrospinal fluid DHAP dihydroxyacetone phosphate G6PD glucose-6-phosphate dehydrogenase GA glyceraldehyde GAPDH glyceraldehyde-3-phosphate dehydrogenase GSG oxidized glutathione GSSG reduced glutathione LC-MS/MS liquid chromatography-tandem mass spectrometry MRI magnetic resonance i...
متن کاملRegulation of the pentose phosphate cycle.
1. A search was made for mechanisms which may exert a ;fine' control of the glucose 6-phosphate dehydrogenase reaction in rat liver, the rate-limiting step of the oxidative pentose phosphate cycle. 2. The glucose 6-phosphate dehydrogenase reaction is expected to go virtually to completion because the primary product (6-phosphogluconate lactone) is rapidly hydrolysed and the equilibrium of the j...
متن کاملPreparative scale enzymatic synthesis of D-sedoheptulose-7-phosphate from -hydroxypyruvate and D-ribose-5-phosphate
An enzymatic method for ready access to D-sedoheptulose-7-phosphate on a preparative scale was developed, based on the irreversible transketolase-catalyzed reaction: β-hydroxypyruvate + D-ribose-5phosphate → D-sedoheptulose-7-phosphate. D-Sedoheptulose-7-phosphate disodium salt was obtained in 81% overall yield determined using a standard curve obtained by LC/MS/MS.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1953
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)49210-1