The Flory isolated-pair hypothesis is not valid for polypeptide chains: Implications for protein folding
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چکیده
منابع مشابه
The Flory isolated-pair hypothesis is not valid for polypeptide chains: implications for protein folding.
Using an all-atom representation, we exhaustively enumerate all sterically allowed conformations for short polyalanyl chains. Only intrachain interactions are considered, including one adjustable parameter, a favorable backbone energy (e.g., a peptide hydrogen bond). The counting is used to reevaluate Flory's isolated-pair hypothesis, the simplifying assumption that each phi,psi pair is sterica...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.23.12565