The Far-Reaching Influence of Hepatic Enzyme-Inducing Antiepileptic Drugs
نویسندگان
چکیده
منابع مشابه
Influence of Enzyme-Inducing Antiepileptic Drugs on Trough Level of Imatinib in Glioblastoma Patients
BACKGROUND Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent glioblastoma multiforme (GBM). CYP3A4 enzyme-inducing antiepileptic drugs (EIAEDs) like carbamazepine, phenytoin, and oxcarbazepine--as well as non-EIAEDs like valproic acid, levetiracetam, and lamotrigine--are frequently used in patients with GBM. Since CYP3A4 is the majo...
متن کاملP450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: A meta-analysis
PURPOSE The prognoses of seizure treatment with P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs after glioma resection surgery were investigated across several clinical studies. However, the results of these studies are inconsistent. We examined the relevant studies and conducted a meta-analysis of these two types of anti-epileptic drugs. METHODS A bibliography search using t...
متن کاملDoes vitamin K prophylaxis prevent bleeding in neonates exposed to enzyme-inducing antiepileptic drugs in utero?
QUESTION One of my epileptic patients takes carbamazepine. She is 36 weeks pregnant and has asked me whether she should start vitamin K to prevent neonatal bleeding. Does current evidence support this practice? ANSWER Recent evidence does not support the notion that newborns of women treated with enzyme-inducing anticonvulsant drugs are at increased risk of hemorrhagic disease. Antenatal vita...
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PURPOSE We previously demonstrated that converting patients from the enzyme-inducers phenytoin or carbamazepine to the non-inducers levetiracetam or lamotrigine reduces serum lipids and C-reactive protein (CRP). We sought to determine if the same changes would occur when patients were switched to topiramate, which has shown some evidence of enzyme induction at high doses. We also examined the e...
متن کاملP 146: The Best New Antiepileptic Drugs to Prevent Orofacial Malformations as Side Effects of Antiepileptic Drugs
Mothers exposed to Antiepileptic drugs (AEDs) are at high risk to born babies with orofacial malformations such as cleft lips. About 9 percent of congenital abnormalities in babies of mothers with epilepsy relates to orofacial abnormalities. Maintaining safe antiepileptic drugs for millions of mothers with epilepsy is very important. Researches show that new AEDs have less side effects than the...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2009
ISSN: 1535-7597,1535-7511
DOI: 10.1111/j.1535-7511.2009.01327.x