The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM
نویسندگان
چکیده
منابع مشابه
The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
INTRODUCTION The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T-cell-dependent protein antigens typically produce IgG and not IgM antibodies. In this study, we analyzed whether a difference exists between the fin...
متن کاملCCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis
INTRODUCTION Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in ACPA(+) RA and differences in treatment outcome between these subpopulations suggest that ACPA(+) and ACPA(-) RA are different disease subsets. The identification of T-helper...
متن کاملA genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
BACKGROUND Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data from genome-wide association studies (GWAS) have only been published from ACPA-positive subsets of RA or from studies that have not separated the two subsets. The aim of the current study is to provide and compare GWA...
متن کاملVariable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection.
Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic. Herein, we demonstrate the frequency of variable-region glycosylation in single-cell cloned mAbs. A total of 14 ACPA mAbs were evaluated for predicted N-linked glycosylation motifs in silico...
متن کاملMRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF
BACKGROUND In rheumatoid arthritis (RA) bone marrow edema (BME, osteitis) and anti-citrullinated protein antibodies (ACPA) are associated with radiographic progression. ACPA have been associated with BME, but it is unknown if this association is confined to ACPA and BME. We performed cross-sectional analysis of the association of ACPA, rheumatoid factor (RF) and anti-carbamylated protein (anti-...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2017
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2017-211533