The Expression Profile of De-N-acetyl Polysialic Acid (NeuPSA) in Normal and Diseased Human Tissue
نویسندگان
چکیده
منابع مشابه
An Antibody to De-N-Acetyl Sialic Acid Containing-Polysialic Acid Identifies an Intracellular Antigen and Induces Apoptosis in Human Cancer Cell Lines
Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently, we showed that two human pathogens expressed a derivative of PSA containing de-N-acetyl sialic acid residues (NeuPSA). Here we show that an epitope identified by the anti-NeuPSA monoclonal antibod...
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T HE SURFACE CHARGE OF MAMMALIAN CELLS is considered to be one of several factors determining the balance between attractive and repulsive forces that operate between the cell periphery and other surfaces of potential contact.1’2 The surface-charge density of the leukocyte may be important in determining surface characteristics such as adhesiveness, deformability, and pseudopod formation. Varia...
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T HE SURFACE CHARGE OF MAMMALIAN CELLS is considered to be one of several factors determining the balance between attractive and repulsive forces that operate between the cell periphery and other surfaces of potential contact.1’2 The surface-charge density of the leukocyte may be important in determining surface characteristics such as adhesiveness, deformability, and pseudopod formation. Varia...
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PURPOSE Among tumor antigens identified to date, cancer-testis (CT) antigens, which are coded by CT genes, are identified as a group of highly attractive targets for cancer vaccines. This study is the first to analyze the mRNA expression and possible correlation with pathologic characteristics of multiple CT genes in a large cohort of colorectal cancer (CRC) patients. EXPERIMENTAL DESIGN The ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.296046