The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Langerhans cell neoplasms, which include histiocytosis and sarcoma, are tumors that originate from dendritic cells. sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features the cell-like phenotype, generally has poorer prognosis more aggressive phenotype than histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) an oncofetal expressed in various cancer types; its expression often associated poor phenotype. Here, we used immunohistochemistry to evaluate IGF2BP3 neoplasms. was scored negative (< 1%) positive (≥ by immunohistochemistry. All 4 patients (100%) 6 of 22 pediatric (age < 18 years) (27.3%) had results for IGF2BP3; however, 16 (72.7%) all 15 adult ≥ result. Among histiocytosis, independent sex, location, prognosis, BRAF V600E staining results. Taken together, these indicate may be helpful marker distinguishing patients.