The Evolution of Triamcinolone Acetonide Therapeutic Use in Retinal Diseases: From Off-Label Intravitreal Injection to Advanced Nano-Drug Delivery Systems

Ophthalmic drug delivery to the posterior segment of eye has been challenging due complex ocular anatomy. Intravitreal injection drugs was introduced deliver therapeutic doses in segment. Different diseases including age-related macular degeneration, diabetic edema, retinal vein occlusions, uveitis, and cystoid among others, have historically treated with intravitreal corticosteroids injections, more recently implants. Triamcinolone acetonide (TA) is most frequently used intraocular synthetic corticosteroid. Using nanoparticle-based TA systems proposed as an alternative injections treatment diseases. From these novel systems, topical liposomes promising strategy. This review oriented exhibit triamcinolone evolution its results treating using diverse platforms.