The evolution of bacterial LuxI and LuxR quorum sensing regulators

The evolution of bacterial LuxI and LuxR quorum sensing regulators.

Quorum sensing is a widespread form of bacterial communication in which individual cells produce and respond to specific N-acyl homoserine lactone signal metabolites. The different autoinducer synthases that generate these signals and the receptor/activator proteins that mediate the cell's response to them constitute evolutionarily conserved families of regulatory proteins known as the LuxI and...

Orphan LuxR regulators of quorum sensing.

Bacteria can modulate their behavior by releasing and responding to the accumulation of signal molecules. This population co-ordination, referred to as quorum sensing, is prevalent in Gram-negative and Gram-positive bacteria. The essential constituents of quorum-sensing systems include a signal producer, or synthase, and a cognate transcriptional regulator that responds to the accumulated signa...

LuxR- and luxI-type quorum-sensing circuits are prevalent in members of the Populus deltoides microbiome.

We are interested in the root microbiome of the fast-growing Eastern cottonwood tree, Populus deltoides. There is a large bank of bacterial isolates from P. deltoides, and there are 44 draft genomes of bacterial endophyte and rhizosphere isolates. As a first step in efforts to understand the roles of bacterial communication and plant-bacterial signaling in P. deltoides, we focused on the preval...

Engineering of Artificial Cellular Circuits Based on the LuxI-LuxR Quorum-Sensing System

Transcriptional Control during Quorum Sensing by LuxR and LuxR Homologues