The Ever-Worsening Antimicrobial Resistance in Enterobacterales; A wakeup call

Objective: To determine the comprehensive antibiotic susceptibility profile of carbapenem-resistant Enterobacterales among clinical samples received at Armed Forces Institute Pathology (AFIP), Rawalpindi.
 Study Design: Cross-sectional study.
 Place and Duration Study: Department Microbiology, Rawalpindi Pakistan, from Apr to Sep 2020
 Methodology: Over six months, 150 were isolated ofPathology, Pakistan. The antimicrobial testing was performed using Kirby-Bauer Disk-Diffusion technique, their interpreted according CLSI 2020 EUCAST guidelines.
 Results: Out isolates resistant Carbapenems, 99(66%) identified as Klebsiella Pneumoniae, followed by Escherichia Coli 38(25.7%), Proteus Mirabilis 7(4.6%), Enterobacter Cloacae, Serratia Marcescens, Citrobacter Freundii, Providencia retgerii 1(0.6%) each. highly following categories antibiotics tested. For Penicillins/Cephalosporins combinations, resistance range between 94 100%, it >79% for Aminoglycosides, >97% Fluoroquinolones >48% Tetracyclines. Isolates showed highest Colistin, 94(92%) out 102 then Tigecycline 81(81%) 100, Fosfomycin 60(78.9%) 76, Minocycline 41(52%) 79 Doxycycline 33(50%) 66.
 Conclusion: Extensively drug-resistant ‘Superbugs’ with ever-worsening threaten human race back pre-antibiotic era. This real menace cautions against lack antimicrobials treating lethal hazardous infections caused such difficult-to-treat bacteria in times come.