منابع مشابه
NOX Family NADPH Oxidases
Proton channels allow cells to extrude excess acid with a high efficiency and therefore are one of the important homeostatic mechanisms that maintain the intracellular pH in a range compatible with life. Proton currents are highly expressed in phagocytes where they are thought to contribute to charge and pH compensation during NADPH oxidase activation. By analogy with the cytochrome C oxidase o...
متن کاملThe happy family of cytochrome oxidases.
Introduction The enzymes which comprise the prokaryotic and eukaryotic respiratory chains are typically membrane-bound multi-subunit complexes. In mitochondria they tend to be more complex protein conglomerates than in bacteria. In both eubacteria and archaebacteria respiratory enzymes seem to contain only the functional cores of their eukaryotic sisters. In the simplest cases they may have onl...
متن کاملERV-L elements: a family of endogenous retrovirus-like elements active throughout the evolution of mammals.
We have previously identified in the human genome a family of 200 endogenous retrovirus-like elements, the HERV-L elements, disclosing similarities with the foamy retroviruses and which might be the evolutionary intermediate between classical intracellular retrotransposons and infectious retroviruses. Southern blot analysis of a large series of mammalian genomic DNAs shows that HERV-L-related e...
متن کاملBiological roles for the NOX family NADPH oxidases.
Linking the phagocyte defect in patients with chronic granulomatous disease (CGD) with the biochemical basis for oxygen consumption by stimulated neutrophils (1) represented a seminal advance in understanding the molecular basis for a key component of innate immunity. In subsequent decades, the catalytic and regulatory elements of the “respiratory burst oxidase” were elucidated, tacitly assumin...
متن کاملRole of Nox family NADPH oxidases in host defense.
The phagocytic NADPH oxidase is recognized as a critical component of innate immunity, responsible for generation of microbicidal reactive oxygen species (ROS). This enzyme is one representative of the Nox family of oxidases (Nox1-Nox5, Duox1, and Duox2) that exhibit diverse expression patterns and appear to serve a variety of functions related to ROS generation. Mounting evidence now suggests ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2008
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2007.11.009