منابع مشابه
The endothelial glycocalyx
Once thought to be a structure of small size and uncertain significance, the endothelial glycocalyx is now known to be an important regulator of endothelial function. Studies of the systemic vasculature have demonstrated that the glycocalyx forms a substantial in vivo endothelial surface layer (ESL) critical to inflammation, barrier function, and mechanotransduction. The pulmonary ESL is signif...
متن کاملThe Endothelial Glycocalyx Promotes Homogenous Blood Flow
P. Mason McClatchey, Michal Schafer, Kendall S. Hunter, Jane E. B. Reusch 5 6 7 Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, 8 Colorado USA 9 10 Department of Medicine, Denver VA Medical Center, Denver, Colorado USA 11 12 Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, 13 Colorado USA 14 15 Division of Cardiology, Depar...
متن کاملEndothelial Glycocalyx and Cardiopulmonary Bypass.
On the outer surface of a human cell there is a dense layer of complex carbohydrates called glycocalyx, also referred to as glycans or the sugar coating on the cell surface, which is composed of a complex array of oligosaccharide and polysaccharide glucose chains that are covalently bonded to proteoglycans and lipids bound to the cell membrane surface. Studies of an intact endothelial glycocaly...
متن کاملThe endothelial glycocalyx protects against myocardial edema.
Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with elec...
متن کاملThe Endothelial Glycocalyx: Visualization and Measurement
The endothelial glycocalyx is a hair-like surface layer mainly consisted of glycosaminoglycans (GAGs) that includes heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA) and its bearing core proteins (syndecan, glypican, and perlecan). This mini review presents the visualization and measurement techniques of the endothelial glycocalyx up to now, providing insight to the diagn...
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ژورنال
عنوان ژورنال: Tissue Barriers
سال: 2013
ISSN: 2168-8370
DOI: 10.4161/tisb.23494