The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?
نویسندگان
چکیده
The centromere is an essential chromatin domain required for kinetochore recruitment and chromosome segregation in eukaryotes. To perform this role, centro-chromatin adopts a unique structure that provides access to proteins maintains stability under tension during mitosis. This achieved by the presence of nucleosomes containing H3 variant CENP-A, which also acts as epigenetic mark defining centromere. In review, we discuss role CENP-A on dynamics centromeric chromatin. We further impact binding CENP-C, CENP-N, CENP-B modulating structure. Based these findings provide overview higher order
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2021
ISSN: ['1089-8638', '0022-2836']
DOI: https://doi.org/10.1016/j.jmb.2020.10.010