The Electrostatic Features of Dengue Virus Capsid Assembly

Dengue virus causes serious diseases and deaths in the world. Understanding fundamental mechanisms of dengue is highly demanded to develop treatments for caused diseases. Here, we present a computational work which focused on stability viral capsid. The interactions among E proteins capsid were studied using several approaches. It was found that electrostatic distribution single protein monomer inhomogeneous, makes an strongly binding with another protein. This reason why all form homodimers as basic units whole capsids. pKa calculations demonstrated folding energy low stable range pH 6–10, different from many other are at certain pH. dependence homodimer shows independent when also 6–10. finding implies can survive wide pH, explain so widely distributed world spreads fast.