The efficacy of intravaginal antibiotic or their combination with different gonadotropins on vaginitis and fertility in ewes synchronized with progesterone impregnated intravaginal sponges

This study was conducted with two experiments to investigate the efficacy of intravaginal antibiotic or their combination different gonadotropin use on vaginitis and fertility in Berrichon ewes. All ewes (n = 106) were synchronized sponges containing 60 mg medroxyprogesterone acetate for 14 days. For first experiment, 50) received 50 enrofloxacin (TRT) sponge prior insertion no treatment (CON) during nonbreeding season. second 56) randomly assigned one four groups (TRT-E; TRT-G; CON-E; CON-G) according presence antibioterapy (TRT CON) variety gonadotropins at withdrawal (equine chorionic gonadotropin-eCG; E, 500 IU) 24 h later after (gonadotropin-releasing hormone-GnRH; G, 10 ?g) breeding Vaginitis odour scored amount/aspect discharge. The addition did not change score (0.65 ± 0.52 vs. 0.79 0.67, p 0.25) vaginal discharge (2.07 0.71 2.25 0.84, 0.26) both experiments. Oestrus response pregnancy rate 88%; 56% TRT 80%; 40% CON experiment (p > 0.05). These parameters 92.3%; 69.2% TRT-E, 86.7%; 53.3% CON-E, 71.4%; 7.1% TRT-G, 64.3%; 21.4% CON-G group. higher 0.002) TRT-E group than TRT-G CON-G. Additionally, oestrus 0.05) 0.0001) eCG (89.2%; 60.7%) GnRH (67.8%; 14.3%) experiment. In conclusion, local antibiotherapy alter fertility. However, reduced compared eCG.