The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review

Bone turnover is the cellular machinery responsible for bone integrity and strength and, in clinical setting, it assessed using markers (BTMs). Acute exercise can induce mechanical stress on which needed remodelling, but to date, there are conflicting results regards effects of varying stimuli BTMs. This systematic review examines acute aerobic, resistance impact exercises BTMs middle older-aged adults whether responses determined by mode, intensity, age sex. We searched PubMed, SCOPUS, Web Science EMBASE up 22nd April 2020. Eligibility criteria included randomised controlled trials (RCTs) single-arm studies that middle-aged (50 65 years) older (>65 a single-bout, acute-exercise (aerobic, resistance, impact) intervention with measurement PROSPERO registration number CRD42020145359. Thirteen were included; 8 (n = 275, 212 women/63 men, mean 57.9 ± 1.5 5 93, 50 women/43 68.2 2.2 years). Eleven aerobic (AE, 7 middle-aged/4 adults), two (RE, both middle-aged). AE significantly increased C-terminal telopeptide (CTX), alkaline phosphatase (ALP) bone-ALP adults. also total osteocalcin (tOC) men Procollagen I Carboxyterminal Propeptide Cross-Linked Telopeptide Type Collagen women. RE alone decreased ALP In adults, had no effect tOC or BALP, CTX. Impact (jumping) 1 N an effective tool modify BTMs, however, response appears be modality-, intensity-, age- sex-specific. There further need higher quality larger RCTs this area.