The Effect of Topical Nifedipine versus Diltiazem on the Acute Anal Fissure: A Randomized Clinical Trial
نویسندگان
چکیده
Background: The anal fissure is one of the most common anorectal diseases that associated with reduced quality life and productivity loss. We aimed to compare efficacy topical nifedipine diltiazem for treatment acute (AAF). Methods: This single-blind randomized clinical trial was conducted at Ziaeian hospital, Tehran. Patients an diagnosis were allocated two groups. Group A applied 3 grams 0.3% cream on peri-anal area, three times a day, 8 weeks. B also same amount 2% diltiazem-ointment area period. primary outcome remission in 8th week treatments. duration pain relief, side effect treatment, recurrence rate compared between Results: After weeks 77.4% shown group which significantly higher than 54% (P=0.01). Applying ointment earlier relief (P<0.001). 6 months follow-up, relapse not statistically different groups (16.3% versus 21.4%, respectively). Conclusion: application shorter more AAF diltiazem. However, both methods terms related effects rate.
منابع مشابه
comparison of topical nifedipine with oral nifedipine for treatment of anal fissure: a randomized controlled trial
background medical sphincterotomy has gained popularity as a treatment for anal fissure. calcium channel blockers in topical forms could also be appropriate with low adverse effects. objectives this was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. patients and methods a prospective randomized controlled trial was cond...
متن کاملComparison of Topical Nifedipine With Oral Nifedipine for Treatment of Anal Fissure: A Randomized Controlled Trial
BACKGROUND Medical sphincterotomy has gained popularity as a treatment for anal fissure. Calcium channel blockers in topical forms could also be appropriate with low adverse effects. OBJECTIVES This was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. PATIENTS AND METHODS A prospective randomized controlled trial was ...
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Background: Nipple fissure is one of the most common diseases in breastfeeding which leads to maternal pain and disruption of the mother-infant relationship. Since the most important consequence of nipple fissure is the deprivation of the infant from breast milk, it is very important to prevent and treat this condition. The aim of this study was to investigate the effect of the topical form of ...
متن کاملTopical Diltiazem versus topical Glyceryl trinitrate (GTN) in the treatment of chronic anal fissure: Prospective study
متن کامل
Comparison of topical glyceryl trinitrate with diltiazem ointment for treatment of chronic anal fissure. A randomized clinical trial.
BACKGROUND The aim of this study was to compare the effect of topical glycerol trinitrate ointment (GTN) with topical diltiazem hydrochloride ointment (DTZ) in the treatment of chronic anal fissure. METHOD Prospectively, 102 patients were treated randomly with either GTN ointment (0.2%) or DTZ ointment (2%) couple of times daily for 12 weeks. RESULTS Forty-five patients (88.2%) in group DTZ...
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ژورنال
عنوان ژورنال: Middle East Journal of Digestive Diseases
سال: 2023
ISSN: ['2008-8205', '2008-5249', '2008-5230']
DOI: https://doi.org/10.34172/mejdd.2023.330