The effect of smoking intensity on all-cause and cause-specific mortality—a Mendelian randomization analysis
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Mendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
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چکیده ندارد.
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Appendix 1: sample size requirements for instrumental variable analysis with genetic instruments For given Type 1 and Type 2 error probabilities and study design, the sample size required to detect an effect of size d is proportional to 1/d 2 V, where V is the Fisher information (expectation of minus the second derivative of the log-likelihood of the effect size) from a single observation. For ...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2019
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dyz081