The effect of propylene glycol and polyethylene glycol 400 on physicochemical properties of peel off mask of nanosilver using bioreductor Sweet Orange Peels (Citrus sinensis L. Osbeck)

Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids citric acid, which a bioreductor capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed gel for acne treatment through peel-off mask preparation. Humectants provide moisture, prevent skin irritation regulate the viscosity of Propylene Glycol (PG) Polyethylene 400 (PEG 400) humectants combined obtain good physicochemical properties This study aims determine character effect humectant combinations on preparations. characterization was performed UV-VIS Spectrophotometry, Particle Size Analysis, Scanning Electron Microscope. The PG-PEG F1 (0: 100%); F2 (25%: 75%); F3 (50%: 50%); F4 (75%: 25%) F5 (100%: 0). physical-chemical test 28 days included organoleptic, viscosity, dry time, pH. results produced with maximum absorption nanoparticles at 435 nm, rod morphological shapes measuring 106 ± 10.6 PI 0.26 0.06. Statistical analysis showed combination significantly affected dispersibility, time preparation but nothing decreased increased dispersibility higher concentration propylene glycol caused become longer. Formulas 25%: 75% 75%: 25% meet requirements pH not significant changes during storage room temperature.