The effect of intravenous hydration strategy on plasma methotrexate clearance during intravenous high-dose methotrexate administration in pediatric oncology patients
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چکیده
منابع مشابه
Treatment of acute lymphocytic leukemia by high-dose intravenous methotrexate.
A pharmacokinetic study of methotrexate levels in blood and cerebrospinal fluid was performed in 42 patients who received one or more courses of high-dose methotrexate at 500 mg/sq m infused i.v. over a 24-hr period. Methotrexate level in the lumbar cerebrospinal fluid reached 1.2 x 10(-7) M at 0.5 hr and remained constant at that level for the 1st 24 hr. Similar methotrexate levels were noted ...
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in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
Population pharmacokinetics of high-dose methotrexate after intravenous administration in Chinese osteosarcoma patients from a single institution.
BACKGROUND High-dose methotrexate (HD-MTX) with folinic acid (leucovorin) rescue is the gold standard therapy in the treatment of osteosarcoma. The plasma concentration of MTX is closely related to efficacy and toxicity. There are large individual differences. Many authors have described the pharmacokinetic (PK) profile of MTX regarding osteosarcoma under a variety of circumstances. However, no...
متن کاملEarly recognition of patients with decreased methotrexate clearance following high-dose methotrexate infusion therapy.
The purpose of this study was to identify the patients with decreased methotrexate (MTX) clearance as early as possible after the start of high-dose methotrexate (HD-MTX) infusion. Fifty-six patients (age: 18 approximately 83 years) received a HD-MTX infusion (dosage: 1.9 approximately 3.8 g/m2) for 6 h. These patients were retrospectively divided into a low-clearance group and a high-clearance...
متن کاملAppearance of a methotrexate binding plasma protein during high dose methotrexate therapy.
Methotrexate (MTX) is one of the most widely used oncocytotopic drugs. Recently it has been used in extremely high doses (8-15 gms/m) in the treatment of osteosarcoma, non-Hodgkin’s lymphoma and metastatic head and neck cancer. Such high doses facilitate the passive entry of MTX in most solid tumours and thereby provide the necessary tumour cell kill. However, to achieve the desired effects of ...
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2018
ISSN: 1179-1322
DOI: 10.2147/cmar.s172117