The Effect of Intralesional Human Epidermal Growth Factor on Wound Healing in Chronic Diabetic Foot Ulcer: A Retrospective Analysis of Patient Results
نویسندگان
چکیده
Objective: Epidermal growth factor (EGF) plays an important role in wound healing. But, bioavailability of EGF is impaired chronic diabetic foot ulcer (CDFU) due to increased protease activity. The study's objective was evaluate the effect intralesional human-EGF (h-EGF) on healing patients with CDFU. Material and Methods: Twenty-eight CDFU were included study. 75 µg h-EGF thrice a week for 5 weeks used accelerate Ulcer size calculated by simple planimetric measurement. Specimens culture taken from all patients. Granulation response evaluated grade (HG) [HG-0 → no response, HG-I minimal HG-II partial HG-III complete response] closure. Pre- post-treatment ulcers recorded asses treatment outcome. Results: New granulation tissue over (HG I-III) present 26 (92.8%) at end treatment. Complete III) achieved 10 (35.7%) patients, closure seen 3 (10.7%) Pre mean 23.9±18.5 6.5±4.8 cm2 (p=0.001). most frequent adverse events tremor (32.1%). Total 47 causative bacterias (14 different types bacteria) isolated 23 (87.2%) whereas cultures sterile (17.8%) Primarily, Escherichia coli, Proteus mirabilis, Acinetobacter baumannii, Pseudomonas aeruginosa species rate 19.1%, 17%, 12.7%, 10.6% respectively. Conclusion: Intralesional effective CDFU, has serious side-effect accelerates
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چکیده ندارد.
15 صفحه اولHuman epidermal growth factor enhances healing of diabetic foot ulcers.
OBJECTIVE To study the healing effect of recombinant human epidermal growth factor (hEGF) on diabetic foot ulcers. RESEARCH DESIGN AND METHODS A total of 127 consecutive patients were screened and 61 diabetic subjects were recruited into this double-blind randomized controlled study. Predetermined criteria were used for diagnosis and classification of the diabetic wound. The patients were ran...
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ژورنال
عنوان ژورنال: Turkiye Klinikleri Journal of Dermatology
سال: 2022
ISSN: ['1300-0330']
DOI: https://doi.org/10.5336/dermato.2022-90463