The Effect of Hyoscine and Atropine on the Lower Oesophageal Sphincter

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Effect of atropine on gastro-oesophageal reflux and transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease.

BACKGROUND Atropine reduces the rate of reflux episodes in normal subjects by inhibition of transient lower oesophageal sphincter (LOS) relaxations. The aim of this study was to investigate the effect of atropine on the rate and mechanisms of reflux in patients with reflux disease. METHODS Oesophageal motility and pH were recorded for one hour after a meal in 15 patients with reflux disease. ...

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ژورنال

عنوان ژورنال: Anaesthesia and Intensive Care

سال: 1977

ISSN: 0310-057X,1448-0271

DOI: 10.1177/0310057x7700500306