The Drosophila BMP Type II Receptor Wishful Thinking Regulates Neuromuscular Synapse Morphology and Function
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The Drosophila BMP Type II Receptor Wishful Thinking Regulates Neuromuscular Synapse Morphology and Function
Proper synaptic development is critical for establishing all aspects of neural function including learning, memory, and locomotion. Here, we describe the phenotypic consequences of mutations in the wishful thinking (wit) gene, the Drosophila homolog of the vertebrate BMP type II receptor. Mutations in wit result in pharate lethality that can be rescued by expression of a wit transgene in motor ...
متن کاملwishful thinking Encodes a BMP Type II Receptor that Regulates Synaptic Growth in Drosophila
We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evok...
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Amidated neuropeptides of the FMRFamide class regulate numerous physiological processes including synaptic efficacy at the Drosophila neuromuscular junction (NMJ). We demonstrate here that mutations in wishful thinking (wit) a gene encoding a Drosophila Bmp type 2 receptor that is required for proper neurotransmitter release at the neuromuscular junction, also eliminates expression of FMRFa in ...
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Synaptic plasticity involves the modulation of synaptic connections in response to neuronal activity via multiple pathways. One mechanism modulates synaptic transmission by retrograde signals from the post-synapse that influence the probability of vesicle release in the pre-synapse. Despite its importance, very few factors required for the expression of retrograde signals, and proper synaptic t...
متن کاملWishful Thinking
and we will write to you when there is a bed available yes I know it's painful, and six months is a long time to wait, but I am afraid we have already lost two wards this year because of the cuts. Mrs Thatcher keeps taking money away from us to spend on Trident Missiles Yes I wish you would write to your Member of Parliament about it. Hello Sister, is it tea time yet? Sister: Not yet I'm afraid...
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ژورنال
عنوان ژورنال: Neuron
سال: 2002
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(02)00595-0